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ITI® Herbal Formulas for 30 yrs.

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Resveratrol Anti Aging Extract

Resveratrol Supplements

The High-Potency Rejuvenation Formula
Shield yourself from the aging effects of free radicals and oxidative stress! Resveratrol-Ultra activates the longevity enzyme, boosts antioxidants and enhances heart health.

A severe low-calorie diet causes your body to release a longevity enzyme that slows aging. Studies show that resveratrol duplicates the effects of calorie restriction and activates this enzyme without dieting!

Resveratrol Ultra contains 3 times more resveratrol than other leading resveratrol products. Equals the amount of trans-resveratrol (the most active form) contained in 43 bottles of red wine.

. 60 Capsules

Supplements Facts

Serving Size: 2 Capsules Amount/Serving %DV

Proprietary Longevity Blend™† 650 mg *
French whole wine grape and giant knotweed root and rhizome extracts containing:
Resveratrol............................125 mg
as 100% trans-resveratrol, the most biologically active form of resveratrol

Japanese Sophora (Sophora japonica) Flower Bud Extract 150 mg *
standardized to contain 90% rutin

*Daily Value (DV) not established.
Other Ingredients: vegetable capsule (modified cellulose), rice maltodextrin, soy lecithin, mixed tocopherols (antioxidant), magnesium stearate, silicon dioxide, and soybean oil.
Contains No:
sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, preservatives or ingredients of animal origin. This product contains natural ingredients; color variations are normal.

Japanese knotweed extract (Polygonum Cuspidatum) is  a concentrated source of resveratrol.

Very recently, it was reported that Giant knotweed extract is one of the best active-oxygen scavengers for the prevention of skin aging induced by UV-irradiation and free radicals.
Where will Giant Knotweed Extract used to?
Anti-lipid oxidation
Heart disease prevention
Anti-platelet aggregation
Smoothes blood vessels
Decreases blood lipid

Giant knotweed is native to east Asia, and has been used in traditional Chinese medicine since the first century BC. It is an excellent source of the antioxidant phenol resveratrol (also found in red wine) which is produced by the plant in response to fungi.

The root of Japanese knotweed (Polygonum multiflorum aka "He Sho Wu") is the richest known source of resveratrol. It has long been used in a variety of herbal medicines in China and Japan, where it is considered a tonic and life prolonging plant.

Most of the resveratrol-containing supplements which are marketed in the U.S. contain extracts of the root of Polygonium cuspidatum.

The stereoisomer of resveratrol found in grapes and peanuts is the trans-form. Both cis- and trans-resveratrol are found in Polygonium cuspidatum.

Japanese Sophora - Rutin
 has strong antioxidant properties. Rutin has also the property to chelate metal ions, such as iron, thereby reducing the Fenton reaction (production damaging oxygen radicals). Rutin also seems to stabilize vitamin C. If rutin is taken together with vitamin C, the activity of ascorbic will be intensified.
Rutin is important because it strengthens capillaries and can help people who bruise or bleed easily. Studies have demonstrated that rutin can help to stop venous edema, that is an early sign of chronic venous disease of the leg.
Rutin has anti-inflammatory effects. Animal studies have shown that rutin has preventive and healing effects.
There are indications that rutin can inhibit some cancerous and pre-cancerous conditions.
Rutin may help to prevent atherogenesis and reduce the cytotoxicity of oxidized LDL-cholesterol.

1 Bottle $22.95
Save 10% 6 Bottles $123.95


Resveratrol has several activities that may account for its possible cardioprotective action. These include inhibition of the oxidation of low-density lipoprotein (LDL), inhibition of smooth muscle cell proliferation and inhibition of platelet aggregation. Resveratrol has also been found to reduce the synthesis of lipids in rat liver and to inhibit the production of proatherogenic eicosanoids by human platelets and neutrophils.

Resveratrol's antioxidant activity may play an important role in its possible cardioprotective action. Above, was mentioned its ability to inhibit the oxidation of LDL. Resveratrol also has been found to exert a strong inhibitory effect on superoxide anion and hydrogen peroxide production by macrophages stimulated by lipopolysaccharides or phorbol esters. It also has been demonstrated to decrease arachidonic acid release induced by lipopolysaccharides or phorbol esters, or by exposure to superoxide or hydrogen peroxide. It has hydroxyl-radical scavenging activity and has recently been found to possess glutathione-sparing activity.

In a rat study of the effect of resveratrol on ischemia-reperfusion, it was found that the substance had a dramatic effect against ischemia-reperfusion-induced arrhythmias and mortality. Resveratrol pretreatment both reduced the incidence and duration of ventricular dysrhythmias, including ventricular tachycardia and ventricular fibrillation. Resveratrol pretreatment also increased nitric oxide and decreased lactate dehydrogenase levels in the carotid blood. In this example, the cardioprotective effect of resveratrol may be correlated with its antioxidant activity, upregulation of nitric oxide synthesis and protection against endothelial dysfunction.

Resveratrol's possible phytoestrogenic activity may also contribute to its possible cardioprotective action. Resveratrol appears to act as a mixed agonist/antagonist for estrogen receptors alpha and beta. It has been found to bind estrogen receptor beta and estrogen receptor alpha with comparable affinity but with 7,000-fold lower affinity than estradiol. Resveratrol differs from other phytoestrogens, which bind estrogen receptor beta with higher affinity than they bind estrogen receptor alpha. Resveratrol also shows estradiol antagonistic behavior for estrogen receptor alpha with some estrogen receptors. It does not show estradiol antagonistic activity with estrogen receptor beta.

Resveratrol's possible antiproliferative activity also may be accounted for in several different ways. Resveratrol's antioxidant activity was discussed above. It also has antimutagenic activity, as illustrated by its dose-dependent inhibition of the mutagenic response induced by treatment of Salmonella typhimurium strain TM677 with 7,12-dimethylbenz(a)anthracene (DMBA). Resveratrol has been found to inhibit cellular events associated with tumor initiation, promotion and progression. It has been found to inhibit cyclooxygenase (COX) activities in different cancer models, suggesting an effect at the level of tumor promotion. It has also been found to reverse tumor-promoter-induced inhibition of gap-junctional intracellular communication in rat epithelial cells. Inhibition of gap-junctional intracellular communication is an important mechanism of tumor promotion.

Resveratrol Dosage

All information is for informational purposes only, and not intended to diagnose, treat, cure or prevent any disease. No statements have been evaluated by the FDA. We always suggest talking to your physician concerning any questions you may have about supplement/drug interactions.